Technology
The NovaPLEX family of technology is founded on unique proprietary chemistry to address the drivers the of genetic analysis market, namely
- Use of new sample types, quantities, and form
- Greater sensitivities and faster protocols
- Improved workflows and automation
- Lower cost per result outcome
| PicoPLEX | OmniPLEX | ThruPLEX | |
|---|---|---|---|
| Chemistry Principle | Prepares pg input DNA samples or whole cells (e.g. single human cells) for PCR and microarray analysis using a cell lysis and thermal cycling library synthesis followed by extreme low background amplification. |
Prepares ng input purified DNA/RNA samples for PCR and microaarray analysis using an isothermal, quasi-random primed library synthesis followed by low background amplification. |
Prepares pg to ng fragmented DNA or cDNA for NGS analysis using multiplexed enzyme reactions for efficient repair and blunt end ligataion library synthesis followed by high fidelity amplification. |
| Applications |
- IVF: PGS/PGD |
- Fixed/frozen tissue (cancer) |
- Fixed/frozen tissue (cancer) |
| Commercial Products |
GenomePLEX WGA (Offer by Sigma for Research Only) TransPLEX WTA (Offer by Sigma for Research Only) |
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| History |
Protected by US Patent 8,206,913 and pending. PicoPLEX is currently commercialized as PicoPLEX Single-Cell WGA kits. Launched in 2009, these kits are the gold standard for genetic testing of human blastomeres, polar bodies, and trophectoderm to support in vitro fertilization, including pre-implantation screening and diagnosis.fertilization, including pre-implantation screening and diagnosis. |
Protected by US Patent 7,718,403; EP1604040. OmniPLEX technology is currently commercialized as GenomePLEX® C-WGA and TransPLEX® C-WTA kits. Launched in 2003 and 2004, these kits are used for human, animal, plant, and environmental diagnostic applications. |
Protected by US 7,803,550 and EP1924704. ThruPLEX is currently commercialized as ThruPLEX-FD Prep kits for high throughput, high-sensitivity NGS on Illumina platforms for both diagnostic and research applications. |