Company Literature
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Oct. 1, 2006
ABSTRACT: Human cancer is characterized by abnormal patterns of methylated DNA (meDNA) involving thousands of genes. The pattern of methylation in a small subset of genes can be used as a very sensitive and specific diagnostic or prognostic test for cancer. For example, published data shows that prostate cancer could be detected with a sensitivity and specificity of nearly 100% by detecting the methylation status of only ten genes. The challenge is making a non-invasive test that would have the same sensitivity and specificity as a tissue test.